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454 Moreover, centrally mediated factors, such as cognitive processes (e.g., attention, distraction, catastrophizing), contextual beliefs about pain, and emotional states (e.g., depression, anxiety), significantly influence the pain experience

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10.1016/S0011-393X(98)85006-6 2 AbbasN

The transcription factor specificity protein 1 (SP1) has the ability to attach to the BACH1 gene's promoter region, thereby controlling its fundamental level of expression