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2017;5:Article 162

It triggers the nonclassical nuclear factor kappa-B (NF-B) signaling pathway, produces cytokines and chemokines, promotes inflammation, and damages cellular function ( 1177 in endothelial cells (ECs) to produce nitric oxide (NO) to maintain normal endothelial function ( Intracellular hyperglycemia can increase production of advanced glycation end products (AGEs), promoting the interaction of AGEs and the advanced glycosylation end product-specific receptor (AGER, also known as RAGE)

Takahashi T, Katada S, Onodera O

Comparison of synthetic membranes to heat-separated human epidermis in skin permeation studies in vitro

(7), [ln F= ln F 0 - k t], a plot of [ln F]vs [t] is shown in Figure 8