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Common side effects include: Injection site reactions mild pain, redness, swelling, or bruising at the injection site, typically resolving within a few days Headache usually transient and manageable with standard analgesia Nausea or dizziness particularly in the initial treatment phase Skin reactions including itching, mild rash, or acneiform eruptions Temporary urine discolouration red or orange urine is harmless and expected Diarrhoea or flushing usually mild and self-limiting In patients with severe megaloblastic anaemia, low potassium levels (hypokalaemia) may occur during initial intensive treatment, but this is uncommon in routine maintenance therapy
Genetic as well as pharmacological inhibition of Epha4 signaling was able to rescue the mutant SOD1 phenotype in zebra fish and increased survival in mouse and rat models of ALS by promoting neuromuscular re-innervation in late stages of ALS[39]
CAMKK2 rs1063843 is associated with reduced CAMKK2 mRNA expression [45], consistent with the idea of reduced mitochondrial function and energy generation in bipolar depression
2025 May:140:156484
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