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3.1.2 Vaccine trials based on whole Babesia parasites Using whole Babesia live or inactivated parasites in vaccination approaches has important advantages, since they should include most, if not all, antigens expressed at least in certain stages of the organisms, and in some cases, such as in live attenuated vaccines, they may overcome limitations due to antigenic variation and natural polymorphism (72), although this may depend on the method used to reduce the virulence of the parasites

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