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Understanding Drug Half-Life: Calculations, Curves, and Clinical Relevance Drug half-life (t) is a core concept in pharmacokinetics that shows up on every major examand in every rotation

It was also reported in DRG neurons of wild type and TRPV4 knockout mice that activation of TRPV4 by paclitaxel induced mechanical allodynia and excessive ROS production, although the allodynia and oxidative stress was partially decreased by the TRPV4 antagonist treatment (Materazzi et al., 2012) (Table 1)

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