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Reports of the Surgeon General Murray CL, Abraham J, US Burden of Disease Collaborators, et al .: The state of US health, 1990-2010: Burden of diseases, injuries, and risk factors

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The carcinogens present in tobacco smoke, such as benzene, formaldehyde, and polycyclic aromatic hydrocarbons, damage the DNA in lung cells, leading to the uncontrolled growth of cancer cells