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Biofilm-forming organisms may contribute to: Ongoing inflammatory signaling Reduced melanocyte-stimulating hormone (MSH) Impaired immune resolution (17) Because biofilms protect organisms from immune clearance, unresolved colonization may perpetuate inflammatory patterns even after environmental exposure has been addressed
This redox impairment would lead to a buildup of hydrogen peroxide, which could trigger inflammation by promoting the activity of the mitogen-activated protein kinase (MAPK), NF-B, and the nuclear NOD-like receptor (NLR) family pyrin domain containing 3 (NLRP3) inflammasome [68]
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TrkB receptor activation BDNF is synthesized as a precursor protein called proBDNF, which is cleaved by proteases into its mature form
