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Description

Unlike traditional methods that rely on internal coordinate systems, the Cartesian_ddg protocol minimizes the energy in Cartesian space, allowing for finer adjustments to the proteins structure

However, some individuals may experience mild side effects such as gastrointestinal discomfort

N Engl J Med 347:111121

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Yet, in the body, (1) -tocopherol is preferentially retained in the liver by the binding to -tocopherol transfer protein (-TTP), which incorporates -tocopherol into lipoproteins for delivery to extrahepatic tissues