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Pickart's original fractionation work documented that plasma GHK-Cu activity declines with age, though the precise concentration values he reported have been cited and recalculated variably across secondary sources

Oral preparations of Vitamin B12 may increase serum levels but many patients remain symptomatic until they use sublingual or vitamin B12 injections due to low cellular concentrations 6

Always speak with your doctor when taking any new medication or supplementation

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