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Improvement of endothelial function in patients with hypertension and type 2 diabetes after treatment with telmisartan

The metabolism of catalpol in rats is mainly mediated by the intestinal microbiota, resulting in the formation of an aglycone-containing hemiacetal hydroxyl structure (Liu, 2014)

Animals are dosed according to body weight (usually at 400600 mg/kg body weight [46,47,48]), though an argument has recently been made for dosing to be conducted according to lean body mass, at least in obese animal models [49]

10.1016/j.bbrc.2024.149733 60 FarinelliL.RiccioM.GiganteA.De FrancescoF