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Sci Rep (2016) 6:19295

In animals, specifically DR in its various forms (CR/IF/STS, KD, protein restriction) has shown a potential for simultaneously targeting many of the pathways associated with insulin and IGF signaling, usually with no serious, or with even beneficial side effects such as a differential stress response between normal and tumor tissue

The discrepancy between the 500 mg dose and higher weight-based doses often comes down to absorption

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Samples were prepared in triplicate and were stored in the dark at 42 C with 25% relative humidity (RH) in an accelerated degradation chamber, as 2 weeks storage under these conditions is equivalent to approximately 6 weeks storage under ambient conditions [29, 30]