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Novel Mechanisms for Heme-dependent Degradation of ALAS1 Protein as a Component of Negative Feedback Regulation of Heme Biosynthesis

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One of the key molecular sensors driving this adaptation is AMP-activated protein kinase (AMPK)

RNA-Seq data analysis of bronchoscopy brushings

Thus, miRNA dysregulation represents a layer of ferroptosis control embedded within canonical TGF- signaling, contributing to the chronic epithelial injury and maladaptive repair that characterize IPF