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found that PDT treatment of colorectal cancer cells with a photosensitizer that specifically targets mitochondria induced elevated levels of mitochondrial ROS in the cells and induced colorectal cancer cells pyroptosis via the caspase 3/gasdermin E pathway

This would impair its potential for in vivo or clinical translation

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World Kidney Day: Chronic Kidney Disease (2015) Accessed 1 Mar 2023 Wright E Jr, Scism-Bacon JL, Glass LC (2006) Oxidative stress in type 2 diabetes: the role of fasting and postprandial glycaemia