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Upregulation of TXNIP by ROS stimulated the NLRP3 inflammasome, which activated the protease caspase-1 to facilitate the release of inflammatory cytokines such as interleukin-18 (IL-18) and interleukin-1 (IL-1) and triggered inflammatory responses

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Clin Exp Pharmacol Physiol 33:725733 McKenna MC, Scafidi S, Robertson CL (2015) Metabolic alterations in developing brain after injury: knowns and unknowns

Diabetologia 58 , 781790 (2015)