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However, the T1273A mutation did not bind less well to COPII and so the reduced cell surface expression is likely to reflect increased COPI binding rather than a reduction of interaction with COPII

Oleanolic acid-derived bardoxolone methyl, a dual activator of Nrf2 and inhibitor of the NF-B pathway, entered clinical trials for the treatment of diabetic nephropathy and chronic kidney disease (de Zeeuw et al