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The intervention of RA-FLSs with resveratrol significantly increases the expression of Nrf2 and HO-1, reduces the production of ROS and MDA and activation of nuclear factor kappa-B (NF-B) p65, inhibits the proliferation and migration of RA-FLSs, and promotes its apoptosis (114, 115)

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however, given the limited vascular supply to the inner meniscus, and hence healing abilities, injuries there usually require resection of the damaged tissue