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Based on the results reported here, we have a thorough understanding of the mechanism about ACTL6A regulating GCLC, GSH metabolism, and ferroptosis

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2.1.1 Dysregulation of iron homeostasis Iron, an essential micronutrient for biological processes (Forbes, 2009), serves critical functions across various metabolic pathways, such as facilitating oxygen transportation, supporting energy metabolism, aiding nucleotide synthesis, and participating in electron transport