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Four predictors influence drug distribution, including volume of distribution (VDss), fraction unbound, blood-brain barrier (BBB) permeability, and Central Nervous System (CNS) permeability

TABLE 2 Comparison of the Two Most Common Variants of G6PD Deficiency Diagnosis The diagnosis of G6PD deficiency is made by a quantitative spectrophotometric analysis or, more commonly, by a rapid fluorescent spot test detecting the generation of NADPH from NADP