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Conversely, DIO3, primarily located in the brain, placenta, and pancreas, inactivates T4 and T3 by converting T4 to reverse T3 (rT3) and T3 to diiodothyronine (T2) [20, 21] (Fig

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H&E staining results further confirmed that the aortic wall thickness of mice treated with FOXO4-DRI was significantly thinner, and ultrasound examination results showed that the PWV of the aorta was slowed down after FOXO4-DRI treatment, indicating better vascular elasticity and significantly improved vascular function compared to the control group (Figures 2D,E)