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published Phase I safety data in healthy volunteers were reported in conference proceedings, while completed Phase II efficacy results have not appeared in peer-reviewed literature

- Dan Leffler, Takeda The trial was the first to demonstrate that autoimmunitys holy grail may be within reach

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FOXO4-DRI effectively disrupts the p53-FOXO4 interaction (Fig

Another small molecule, AMG 337, which is a selective inhibitor targeting c-Met has also been reported (Van Cutsem et al., 2019)