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Animals were housed in a neutral temperature environment (22C 2C) on a natural day-to-night cycle with free access to water and on a standard diet

This is unlike the use of supplements, which are usually digested by the stomach acids before they can be absorbed into the bloodstream to reach the skin cells

KPV is a short peptide fragment referenced in preclinical literature for its association with immunomodulatory signaling and pathways linked to inflammatory response mechanisms

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These findings suggest that the specific microenvironment may be affected by the absence of non-epithelial cell types, although hormone-regulatory mechanisms are present in the organoids