Early evidence for the potential efficacy of this route was published in 1999, where 18 patients with B12 deficiency treated exclusively with 712 days of 2 mg of sublingual cobalamin daily had 4 times higher B12 levels compared to pre-treatment, reaching therapeutic ranges ( There have also been further studies comparing treatment outcomes from the sublingual route to the more established IM and oral routes
Moderating alcohol intake is recommended since excessive consumption can negatively affect Vitamin B12 levels
Similarly, examining how acute and/or repeated applications of neuropeptides affect expression of mucins (e.g., muc5AC, muc5B) in asthma, COPD, and CF would reveal a potentially causative role for neuropeptides in airway mucus phenotypes
If the dose falls below the true human MED, the result is delayed healing and wasted product, failing to resolve the chronic tendinopathy
The GHK-Cu injection guide walks through several reconstitution scenarios