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APE1 interacts with several proteins involved in both DNA repair and redox regulation
Compared to cytosolic NADK (cNADK), mitochondrial NADK (mNADK) has a distinctive feature that it can directly phosphorylate nicotinamide adenine dinucleotide (NADH) to generate NADPH to alleviate oxidative stress in mitochondria
Moreover, functional MRI studies have demonstrated impaired connectivity within the default mode network in T2DM patients
For example, ATP synthasea vital mitochondrial enzymerequires HSPA9 for the proper assembly of its motor components, F 0 and F 1
Hereditary hemochromatosis and osteoporosis Beyond metabolic disorders such as diabetes mellitus and obesity, genetically determined diseases characterized by systemic iron overload may provide further insight into the role of ferroptosis in bone pathology
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