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Because TG2 activity is highly associated with cellular redox status and alterations in the bidirectional flux of cellular thiol modulate TG2 activity, regulation of thiol flux in cells probably affects the TG2-mediated aggregation of the GST tag and its interaction with cellular proteins

22 Whilst evidence is limited, it consistently reports a benefit of B12 for aphthous ulcers regardless of B12 status

Alternating between the abdomen, thigh, and upper arm areas prevents lipohypertrophy and maintains consistent absorption

Treatment Protocol Research Limitations Moderate sample size (n=45)

Expected duration of vitamin B12 deficiency With proper treatment, symptoms of vitamin B 12 deficiency begin to improve within a few days