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These findings suggest that NNMT inhibition may influence tumor cell line phenotypes in vitro through both metabolic and epigenetic mechanisms, making 5-amino-1MQ a valuable tool for investigating the metabolic characteristics of different tumor cell lines

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These neurotransmitters act on - or -adrenergic receptors, which are typically G-protein coupled receptors 68

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Another mechanism would be an elevation in endogenous diacylglycerol (DAG) levels which can activate tyrosine kinase-inducing melanogenesis (Videira et al., 2013)

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