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Rats received AOD 9604 daily for 6 months and cynomolgus monkeys for 9 months

The absence of FDA approval means that use represents an off-label application requiring informed consent and medical judgment

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doi: 10.1080/00480169.1998.36089

Another case involved a 52-year-old woman who had a severe anaphylactic reaction to the injection but tolerated oral Vitamin B12 without issues