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Mitophagy inhibits amyloid- and tau pathology and reverses cognitive deficits in models of Alzheimer's disease
31,32 In diabetic peripheral neuropathy (DPN), macrophages infiltrate to initiate repairment on nerve injury, with more cytokine and chemokine released
Immune Dysregulation and Sustained Inflammatory Signaling Repeated exposure can sustain immune activation beyond its normal protective role
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Moreover, using conditional knockout mouse models (e.g., chondrocyte-specific Trpv1 / or Slc2a1 / ), the protective effects of CAT on ferroptosis and OA progression in vivo need to be verified, combined with spatial metabolomics to analyze dynamic changes in lipid peroxidation products and antioxidant molecules in joint tissues following CAT intervention
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