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Drugs manipulate and disable neurochemistry

One of the hallmarks of severe asthma is the depletion of antioxidant defences, including glutathione (GSH) and superoxide dismutase (SOD), both of which help neutralise reactive oxygen species (ROS)

Furthermore, its accumulation also oxidizes phosphatases, protein kinases, and transcription factors comprising thiolate residues

However, it does not fully address the potential unintended effects, such as toxicity or interference with other cellular pathways

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