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Formulations were delivered using a perfusion pump at the rate of 2 L/sec

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The investigators reported concentration-dependent reductions in fat mass and adipose-tissue NNMT activity without significant changes in lean mass or food intake

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Finally, we briefly describe the future of anti-TNF- therapy, including the next generation of anti-TNF- drugs, as well as the possible combination of anti-TNFs with other biologic and targeted therapies