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Tobacco blenders like to use Cavendish because it is mild and sweet whilst moderating the flavours of the other leaves due to it being slow-burning

The user will want to replicate this feeling with future tobacco use

Discussion This study on a cohort of 75 molecularly proven cEDS patients aimed to validate the revised diagnostic criteria and explore the multisystemic involvement of the disorder by comparing types and incidences of the numerous clinical manifestations at different ages and with those observed in other EDS subtypes, in order to delineate natural history and assist differential diagnosis