The method of embodiment3, wherein the chemotherapy-induced ototoxicity is caused by a platinum based chemotherapeutic agent, a bis-platinate, vincristine, an aminoglycoside antibiotic, a macrolide antibiotic, a diuretic or a salicylate
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Therefore, targeting the palmitoylation of PD-L1 and the depalmitoylation of cGAS represents a potential novel strategy to enhance the clinical effectiveness of anti-tumor immunotherapy [64, 65]
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