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GSH AS MAIN REGULATOR OF CELLULAR REDOX STATUS AND REDOX SIGNAL TRANSDUCTION The glutathione redox couple GSH/GSSG has a great importance in the cells and together with other redox-active couples, including NADPH/NADP + , Trx-SH/Trx-SS regulates and maintains the appropriate cellular redox status

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The astonishing fact that free copper is undetectable within cells is due to the existence of copper chaperones, such as CCS which binds and transfers copper directly to its final target Cu, Zn-SOD1 [145, 146]