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This work was funded by the National Heart, Lung and Blood Institute (R01HL095388 to AS and MEL), National Center for Advancing Translational Science (UL1 TR000157 to AS and MEL), National Science Foundation (Integrative Graduate Education and Research Traineeship to JDC and JEZ), British Columbia Lung Association, Canadian Institute for Health Research, Parker B Francis Foundation (Senior Fellowship to TLH) and the Dutch Asthma Foundation and European Respiratory Society (International Research Fellowship to CAB)

The underlying explanation remains unclear

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