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M., Aschner, M., Rashidian, A., Hamblin, M

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Proline is important in cellular homeostasis (cell proliferation or cell death) and can act as a signaling molecule to modulate mitochondrial functions and trigger specific genes expression, which is essential for plant recovery from stresses 20

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Moreover, its mechanisms for managing digestive precancerous lesions are concretely summarized, including anti-oxidative stress effects, anti-inflammatory response and regulation of cell proliferation and apoptosis, especially its modifications on TLR4/TRIF/NF-B signaling pathway and p53-dependent cell cycle control and apoptosis