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Laboratory investigations primarily focus on its influence over fibroblast activity, collagen type I synthesis, and the physiological signaling pathways within isolated follicle cell cultures

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In a similar study, the pivotal role for the IGF-1 in insulin sensitivity has received further support from liver-specific IGF-1 KO mice which exhibited overt insulin resistance and hyperinsulinaemia that was reversed by the administration of IGF-1 [161]

Intramuscular injections are used when other types of delivery methods are not recommended