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Curr Opin Immunol 22(2):231237 Biswas SK et al (2006) A distinct and unique transcriptional program expressed by tumor-associated macrophages (defective NF-kappaB and enhanced IRF-3/STAT1 activation)

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Long-term administration in mice inhibited development of leukemia by 6-fold and reduced total spontaneous tumor incidence, with no increase in cancer risk despite telomerase activationaddressing theoretical concerns about uncontrolled proliferation

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Huang K, Li Z, He X, Dai J, Huang B, Shi Y, et al