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Substance P may stimulate the phosphorylation of p70 S6K1 and inhibit the phosphorylation of p38 MAPK by activating the NK-1R receptor, thereby inhibiting TRP1 by MITF, thus playing an anti-melanin synthesis role (Ping et al., 2012)

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Cagrilintide monotherapy at 4.5 mg weekly achieved 10.8% average weight loss over 26 weeks versus 3% with placebo in its Phase 2 dose-finding trial

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