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Potential theoretical concerns include: Unregulated angiogenesis Immune system modulation Tumor growth acceleration under certain conditions Reproductive safety implications Cardiovascular remodeling There is no clinical evidence demonstrating these risks in humans, but comprehensive trials evaluating these endpoints do not exist

Azadi, S., et al

Some researchers believe that reducing gut inflammation and improving intestinal integrity could indirectly influence mood, cognition, and stress regulation, though this has not been proven clinically

Non-medical usage, such as for immune boost, athletic preparation, or recovery, allows for personal choice in determining injection frequency, with some doctors suggesting a few vitamin B12 injections throughout the year

World journal of cardiology