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The importance of the tumour microenvironment in the progression and treatment response of CRC is well documented, with high infiltration of T-cells associated with improved prognosis (74), suggesting that in addition to tumour cell-specific effects, metformin-mediated modulation of host immunity may also underlie its radiosensitising effects

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The most basic intravenous access consists of a needle piercing the skin and entering a vein which is connected to a syringe or to external tubing