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Am J Prev Med 58(2):182190 Klemperer EM, Hughes JR, Callas PW, West JC, Villanti AC (2021) Tobacco and nicotine use among US adult never smokers in wave 4 (20162018) of the Population Assessment of Tobacco and Health Study

Smoking significantly increases the risk of COPD or chronic obstructive pulmonary disorders, which are a group of lung disorders, causing difficulty in breathing

Higher rates occur with FDA-approved treatment therapies developed for users of combustible cigarettes

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The body loses weight because of ongoing pain and decreased food absorption, from eating less