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Thyroid 19 , 673674 (2009)

This capability enables the development of drug combinations with synergistic effects, a strategy known as multi-drug targeted pharmacology. Studies have demonstrated that multi-target drugs can more effectively address complex diseases [12]

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In fact, the addition of NBDHEX, a strong and specific inhibitor of e-GST and other GST isoenzymes belonging to the alpha, pi and mu classes, 13 did not suppress this additional GST activity (Figure 2b), and curiously the activity was also found in the absence of GSH (Figure 2a)

Duvyzat won approval on the strength of a Phase III study that met the primary endpoint of a change in the four-stair climb assessment from the baseline to 72 weeks and showed favorable outcomes in key secondary measures, according to Italfarmaco