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For children on valproate for epilepsy, which can lead to a deficiency of carnitine (see Interactions section), the doctor will likely prescribe a dose of 100 mg/kg of body weight per day, not to exceed 2,000 mg per day

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In the presence of elevated oxidative stress, such as in iron overload, sarcoplasmic reticulum Ca 2+ leaks through the Ca 2+ release channels (62), sarcoendoplasmic reticulum Ca 2+ -ATPase activity is inhibited, the sodium-calcium exchanger currents are elevated (63), and L-type calcium channels are reduced (64, 65)

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