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Hence, we depicted the polarization molecular map based on the KEGG analysis (Fig

In particular with the CRISPRa approach, the transcriptional activators that are fused to the dCas9 enzyme will increase the length of the construct, such that a combination of sgRNA and dCas9-transcriptional activators will be too large to load onto a single AAV vector

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Overall, whether used for acute exacerbations or over extended periods at higher doses (e.g., 6001,200 mg/day for COPD), NAC is generally very well-tolerated