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While there is not much doubt that traumatic disc herniation can occur in a degenerated segment, 5 and, although documented in biomechanical in-vitro studies, 39 the existence of an isolated annulus fiber rupture with NP herniation caused by a single traumatic event without (proven) pre-existing DD is still debated in the clinical literature

Nrf2 is required for acute exercise-induced increases in mitochondrial biogenesis genes in skeletal muscle, energy consumption, mitochondrial volume, antioxidant activity were reduced after exercise training in mice with impaired Nrf2 expression, in muscle cells of mice, ROS- and NO-regulated mitochondrial biogenesis through the Nrf2/Nrf1-dependent pathway (Merry and Ristow, 2016)