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Cagrilintide was initiated at 0.3 mg for the 0.3 mg group, or 0.6 mg for all higher-dose groups and escalated every two weeks until reaching the final dose

Male Sprague Dawley rats were catheterized as described in the Animals and Surgical Procedures section

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A higher concentration can make it much more difficult to measure out a precise dose, especially if your research requires very small amounts

That is a coherent design goal, but the claimed release pattern needs public dissolution validation