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Bordoni L, Kristensen AM, Sardella D, Kidmose H, Pohl L, Krag SRP, et al

Microbiological Research, 167 (3), 166172

In this process, the ubiquitin-proteasome system (UPS), recognized as the principal proteolytic pathway, becomes highly active under pathological conditions such as metabolic muscle atrophy 34

Scaling such systems up requires control over particle size, drug loading, active-agent ratios [21, 109], linker integrity, ligand density and stimuli-responsive behavior