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In a study with senescence-accelerated mice and normal aging controls, treatment with SF for about a year significantly improved long-term memory and increased hippocampal mRNA and protein levels of peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC1) and mitochondrial transcription factor A (TFAM), both of which are master regulators of mitochondrial biogenesis

doi: 10.1002/fsn3.1128 108 Gonzalez-VicenteAGarvinJL

Functional heterogeneity expresses itself via differences in metabolism, oxygen supply, b-oxidation, amino acid metabolism, gluconeogenesis, glycolysis, ureagenesis, liponeogenesis, and bile acid and bilirubin secretion

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