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Current evidence supports a multifactorial etiology in which more than 90 susceptibility loci, rare monogenic variants (e.g., LRRK2, SNCA, PRKN, and PINK1) and environmental toxicants (pesticides, heavy metals, and solvents) converge on three inter-related pathological hallmarks: oxidative stress, mitochondrial dysfunction and chronic neuroinflammation

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Ishida K, et al

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In summary, molecular imaging data supports the neuropathological observations of the vulnerability of serotonin enervation in aging, mid-life depression, LLD, AD and PD