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These observations support Braaks hypothesis, which postulates that -synuclein pathology, underlying PD, may originate in the GI tract

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Summary of Key Amylin-Based Therapies in Development (April 2026) Cagrilintide is a long-acting amylin analogue under investigation for obesity management, and the combination of cagrilintide with semaglutide (CagriSema) has demonstrated superior weight loss and metabolic benefits compared with either agent alone or placebo in recent clinical trials