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These anaerobes produce metabolites, including short-chain fatty acids, polyamines, ammonia, and volatile amines, that can irritate the epithelium, damage DNA, and cause oxidative stress

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19 Under oxidative stress, the glutathione (GSH) level in cardiomyocytes decreases by 6070%, and the levels of Gln, glutamate and -ketoglutarate (-KG) also decrease significantly, while the enzyme activity of GLS, which converts Gln to glutamate, is enhanced

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D) Bar graph confirming the expected increase in the number of dendritic spines following treatment with vehicle, Nle'-AnglV or dihexa (***p 0.05